| Compound | Melatonin |
|---|---|
| Category | Hormone (injectable unapproved) |
| Class | Other Injectables |
| Evidence tier | Minimal evidence |
| WADA status | Not individually listed; verify current status if subject to testing |
| Sold on this site | No — this is a reference database |
Overview
Melatonin is catalogued here as a hormone (injectable unapproved) and graded at the "Minimal evidence" evidence tier. There is little or no formal study of this compound. Claims rest on anecdote, theory, or very early-stage work; risk data are absent by definition.
The pineal sleep hormone, available as an oral supplement in many countries. Injectable melatonin is not an approved formulation anywhere major and circulates only in unregulated channels.
Mechanism of Action
Melatonin acts on MT1/MT2 receptors to time circadian phase; parenteral pharmacology massively exceeds physiological exposure.
Research and Evidence
Oral melatonin has a decent evidence base for jet lag and shift sleep. No injectable trial evidence exists.
Safety and Side Effects
Injectable dosing is unvalidated; sterility of unregulated vials is the immediate risk.
Frequently Asked Questions
What is the evidence tier of Melatonin?
Melatonin is graded "Minimal evidence" on this site. There is little or no formal study of this compound. Claims rest on anecdote, theory, or very early-stage work; risk data are absent by definition.
Is Melatonin an approved medicine?
No. Minimal evidence means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.
Where can I read the primary studies for Melatonin?
The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.
References
- ClinicalTrials.gov — search for melatonin injection studies. [source]
Evidence tier: Minimal evidence · Last reviewed: 2026-09-05 · Sources cited below.