| Compound | Glutathione |
|---|---|
| Category | Endogenous antioxidant |
| Class | Other Injectables |
| Evidence tier | Clinical-stage |
| WADA status | Not individually listed; verify current status if subject to testing |
| Sold on this site | No — this is a reference database |
Overview
This entry covers Glutathione, a endogenous antioxidant, graded "Clinical-stage" in this catalog's evidence system. This compound has completed or is undergoing formal human trials. Human safety and efficacy are being characterized, but no universal approval exists and results may still fail or be withdrawn.
The body’s principal intracellular antioxidant tripeptide. Injectable use for skin lightening is a widespread unapproved practice; small trials exist without robust outcome evidence.
Mechanism of Action
Glutathione directly quenches reactive species and regenerates other antioxidants; proposed depigmentation mechanisms involve tyrosinase pathway modulation.
Research and Evidence
Small randomized trials of oral and IV glutathione for skin lightening show modest, inconsistent pigment effects; no regulator has approved the indication.
Safety and Side Effects
Case reports of hepatic and renal adverse events with high-dose IV use exist; sterility of compounded vials is the practical risk.
Frequently Asked Questions
What is the evidence tier of Glutathione?
Glutathione is graded "Clinical-stage" on this site. This compound has completed or is undergoing formal human trials. Human safety and efficacy are being characterized, but no universal approval exists and results may still fail or be withdrawn.
Is Glutathione an approved medicine?
No. Clinical-stage means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.
Where can I read the primary studies for Glutathione?
The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.
References
- ClinicalTrials.gov — registered glutathione studies. [source]
Evidence tier: Clinical-stage · Last reviewed: 2026-09-05 · Sources cited below.