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Approved medicine WADA prohibitedGH / growth factors

Sermorelin Acetate

A synthetic fragment of growth hormone releasing hormone that was formerly FDA-approved for diagnostic use and pediatric GH deficiency. The original product was withdrawn from the market, though compounded and research versions circulate.

CompoundSermorelin Acetate
CategoryGHRH 1-29 fragment
ClassGrowth Hormone and Growth Factors
Evidence tierApproved medicine
WADA statusProhibited in sport (or falls under a prohibited class) — see the WADA reference table
Sold on this siteNo — this is a reference database

Overview

Sermorelin Acetate is catalogued here as a ghrh 1-29 fragment and graded at the "Approved medicine" evidence tier. This compound exists as an approved medicine in at least one major jurisdiction. Approval applies to specific, labeled indications and to the regulated product — not to compounded or research-grade copies.

A synthetic fragment of growth hormone releasing hormone that was formerly FDA-approved for diagnostic use and pediatric GH deficiency. The original product was withdrawn from the market, though compounded and research versions circulate.

Mechanism of Action

Sermorelin is the biologically active 1-29 fragment of GHRH; it stimulates pituitary GH secretion while preserving hypothalamic-pituitary feedback regulation.

Research and Evidence

Clinical use in pediatric growth disorders was established decades ago; the approved product was later discontinued for commercial rather than safety reasons. Modern use is almost entirely off-label wellness practice without supporting registrational trials.

Evidence in context: the Growth Hormone and Growth Factors class page collects the shared evidence themes and study-reading guidance for this category.

Safety and Side Effects

Injection-site reactions are the best-documented effect. Chronic off-label use lacks modern safety characterization; it is prohibited in sport as a releasing factor.

Educational notice: this entry describes published research and, where they exist, regulator labels. It is not medical advice and not a recommendation for use. Research-grade compounds have no verified human-safety data.

Frequently Asked Questions

What is the evidence tier of Sermorelin Acetate?

Sermorelin Acetate is graded "Approved medicine" on this site. This compound exists as an approved medicine in at least one major jurisdiction. Approval applies to specific, labeled indications and to the regulated product — not to compounded or research-grade copies.

Is Sermorelin Acetate an approved medicine?

Sermorelin Acetate exists as an approved medicine in at least one major jurisdiction — but approval covers the regulated product and its labeled indications only. Compounded or research-grade versions of the same molecule are not the approved product.

Where can I read the primary studies for Sermorelin Acetate?

The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.

References

  1. ClinicalTrials.gov — search for sermorelin studies. [source]
  2. WADA Prohibited List. [source]
EM
Dr. Elena Marsh, PhDMolecular Pharmacology · Lead Editor

Written and maintained by the editorial team. Medically reviewed by Dr. James Okafor, MD (Internal Medicine).

Evidence tier: Approved medicine · Last reviewed: 2026-09-05 · Sources cited below.

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