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PEG-MGF

A pegylated variant of mechano-growth factor (MGF), the splice variant of IGF-1 produced in muscle after mechanical loading, intended to extend its brief native half-life.

CompoundPEG-MGF
CategoryPegylated mechano-growth factor
ClassGrowth Hormone and Growth Factors
Evidence tierPreclinical
WADA statusProhibited in sport (or falls under a prohibited class) — see the WADA reference table
Sold on this siteNo — this is a reference database

Overview

This entry covers PEG-MGF, a pegylated mechano-growth factor, graded "Preclinical" in this catalog's evidence system. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.

A pegylated variant of mechano-growth factor (MGF), the splice variant of IGF-1 produced in muscle after mechanical loading, intended to extend its brief native half-life.

Mechanism of Action

MGF is an IGF-1 splice isoform upregulated by muscle damage that activates satellite cells; pegylation prolongs circulating half-life from minutes to hours.

Research and Evidence

Animal studies report muscle-repair effects; no human trials of PEG-MGF have been published.

Evidence in context: the Growth Hormone and Growth Factors class page collects the shared evidence themes and study-reading guidance for this category.

Safety and Side Effects

No human safety data; prohibited in sport as a growth factor.

Educational notice: this entry describes published research and, where they exist, regulator labels. It is not medical advice and not a recommendation for use. Research-grade compounds have no verified human-safety data.

Frequently Asked Questions

What is the evidence tier of PEG-MGF?

PEG-MGF is graded "Preclinical" on this site. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.

Is PEG-MGF an approved medicine?

No. Preclinical means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.

Where can I read the primary studies for PEG-MGF?

The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.

References

  1. ClinicalTrials.gov — search for PEG-MGF studies (none registered). [source]
  2. WADA Prohibited List. [source]
EM
Dr. Elena Marsh, PhDMolecular Pharmacology · Lead Editor

Written and maintained by the editorial team. Medically reviewed by Dr. James Okafor, MD (Internal Medicine).

Evidence tier: Preclinical · Last reviewed: 2026-09-05 · Sources cited below.

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