| Compound | MGF (Mechano Growth Factor) |
|---|---|
| Category | IGF-1 splice variant |
| Class | Growth Hormone and Growth Factors |
| Evidence tier | Preclinical |
| WADA status | Prohibited in sport (or falls under a prohibited class) — see the WADA reference table |
| Sold on this site | No — this is a reference database |
Overview
MGF (Mechano Growth Factor) — a igf-1 splice variant — sits in the "Preclinical" tier of this catalog. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.
The native IGF-1 splice variant produced locally in skeletal muscle after loading or injury, central to muscle-repair biology and widely referenced in muscle-building discussion.
Mechanism of Action
MGF activates satellite-cell proliferation following mechanical stress — a physiological repair response — with effects distinct from systemic IGF-1.
Research and Evidence
Biology is well mapped in animals; human therapeutic data do not exist. Native MGF’s half-life is so short that exogenous use of the unmodified peptide is pharmacologically questionable.
Safety and Side Effects
No human safety data for exogenous administration; prohibited in sport.
Frequently Asked Questions
What is the evidence tier of MGF (Mechano Growth Factor)?
MGF (Mechano Growth Factor) is graded "Preclinical" on this site. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.
Is MGF (Mechano Growth Factor) an approved medicine?
No. Preclinical means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.
Where can I read the primary studies for MGF (Mechano Growth Factor)?
The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.
References
- ClinicalTrials.gov — search for mechano growth factor studies. [source]
- WADA Prohibited List. [source]
Evidence tier: Preclinical · Last reviewed: 2026-09-05 · Sources cited below.