| Compound | Matrixyl (Palmitoyl Pentapeptide-4) |
|---|---|
| Category | Cosmetic signal peptide |
| Class | Neuro, Nootropic, and Cosmetic Peptides |
| Evidence tier | Minimal evidence |
| WADA status | Not individually listed; verify current status if subject to testing |
| Sold on this site | No — this is a reference database |
Overview
Matrixyl (Palmitoyl Pentapeptide-4) is catalogued here as a cosmetic signal peptide and graded at the "Minimal evidence" evidence tier. There is little or no formal study of this compound. Claims rest on anecdote, theory, or very early-stage work; risk data are absent by definition.
A palmitoylated pentapeptide used in anti-wrinkle skincare, with a modest body of small cosmetic studies on skin appearance.
Mechanism of Action
The peptide is proposed to signal fibroblasts to increase extracellular-matrix production; palmitoylation aids penetration into the stratum corneum.
Research and Evidence
Small controlled cosmetic studies report modest improvements in wrinkle depth and roughness; effects are cosmetic-grade, not therapeutic.
Safety and Side Effects
Topical cosmetic safety record is favorable in the available literature.
Frequently Asked Questions
What is the evidence tier of Matrixyl (Palmitoyl Pentapeptide-4)?
Matrixyl (Palmitoyl Pentapeptide-4) is graded "Minimal evidence" on this site. There is little or no formal study of this compound. Claims rest on anecdote, theory, or very early-stage work; risk data are absent by definition.
Is Matrixyl (Palmitoyl Pentapeptide-4) an approved medicine?
No. Minimal evidence means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.
Where can I read the primary studies for Matrixyl (Palmitoyl Pentapeptide-4)?
The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.
References
- ClinicalTrials.gov — search for palmitoyl pentapeptide studies. [source]
Evidence tier: Minimal evidence · Last reviewed: 2026-09-05 · Sources cited below.