| Compound | KPV (Lysine-Proline-Valine) |
|---|---|
| Category | Anti-inflammatory tripeptide |
| Class | Healing and Anti-Inflammatory Peptides |
| Evidence tier | Preclinical |
| WADA status | Not individually listed; verify current status if subject to testing |
| Sold on this site | No — this is a reference database |
Overview
This entry covers KPV (Lysine-Proline-Valine), a anti-inflammatory tripeptide, graded "Preclinical" in this catalog's evidence system. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.
A three-amino-acid peptide corresponding to the C-terminal sequence of alpha-MSH, studied in inflammatory models — particularly inflammatory bowel disease — and often discussed in gut-health contexts.
Mechanism of Action
KPV appears to interact with inflammatory signaling pathways, and alpha-MSH-derived peptides have documented anti-inflammatory effects in immune cells. Oral and topical routes have both been examined in models.
Research and Evidence
Published work is dominated by cell-culture and animal models of colitis and skin inflammation. Small exploratory human studies exist, but no registrational-quality trials support therapeutic claims.
Safety and Side Effects
No systematic human safety data are available; the compound is not an approved medicine in major jurisdictions.
Frequently Asked Questions
What is the evidence tier of KPV (Lysine-Proline-Valine)?
KPV (Lysine-Proline-Valine) is graded "Preclinical" on this site. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.
Is KPV (Lysine-Proline-Valine) an approved medicine?
No. Preclinical means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.
Where can I read the primary studies for KPV (Lysine-Proline-Valine)?
The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.
References
- ClinicalTrials.gov — search for KPV peptide studies. [source]
Evidence tier: Preclinical · Last reviewed: 2026-09-05 · Sources cited below.