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PreclinicalNeuro / nootropic / cosmetic

Dihexa

An angiotensin IV analog studied for synaptogenesis in laboratory models, discussed in nootropic communities despite having no human data.

CompoundDihexa
CategoryAngiotensin IV analog
ClassNeuro, Nootropic, and Cosmetic Peptides
Evidence tierPreclinical
WADA statusNot individually listed; verify current status if subject to testing
Sold on this siteNo — this is a reference database

Overview

Dihexa is catalogued here as a angiotensin iv analog and graded at the "Preclinical" evidence tier. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.

An angiotensin IV analog studied for synaptogenesis in laboratory models, discussed in nootropic communities despite having no human data.

Mechanism of Action

Dihexa is reported to be a potent hepatocyte growth factor receptor (c-Met) agonist, promoting dendritic spine formation in cell and animal studies.

Research and Evidence

Evidence is exclusively preclinical. Concerns about hepatotoxicity flagged in early work have not been characterized in humans.

Evidence in context: the Neuro, Nootropic, and Cosmetic Peptides class page collects the shared evidence themes and study-reading guidance for this category.

Safety and Side Effects

No human safety data; potent trophic signaling makes unmonitored use a poor risk.

Educational notice: this entry describes published research and, where they exist, regulator labels. It is not medical advice and not a recommendation for use. Research-grade compounds have no verified human-safety data.

Frequently Asked Questions

What is the evidence tier of Dihexa?

Dihexa is graded "Preclinical" on this site. The evidence base for this compound is dominated by animal and cell-culture studies. Mechanism may be plausible; human benefit and safety are unestablished.

Is Dihexa an approved medicine?

No. Preclinical means the compound has not reached universal regulatory approval; the tier description above explains exactly what level of evidence exists.

Where can I read the primary studies for Dihexa?

The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.

References

  1. ClinicalTrials.gov — search for Dihexa studies (none registered). [source]
EM
Dr. Elena Marsh, PhDMolecular Pharmacology · Lead Editor

Written and maintained by the editorial team. Medically reviewed by Dr. James Okafor, MD (Internal Medicine).

Evidence tier: Preclinical · Last reviewed: 2026-09-05 · Sources cited below.

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