| Compound | Alprostadil |
|---|---|
| Category | Approved PGE1 medicine |
| Class | Other Injectables |
| Evidence tier | Approved medicine |
| WADA status | Not individually listed; verify current status if subject to testing |
| Sold on this site | No — this is a reference database |
Overview
Alprostadil is catalogued here as a approved pge1 medicine and graded at the "Approved medicine" evidence tier. This compound exists as an approved medicine in at least one major jurisdiction. Approval applies to specific, labeled indications and to the regulated product — not to compounded or research-grade copies.
Prostaglandin E1 approved for erectile dysfunction (Caverject injectable, MUSE urethral) and for maintaining ductus arteriosus patency in neonates.
Mechanism of Action
PGE1 relaxes cavernosal smooth muscle via cAMP signaling, producing arterial inflow.
Research and Evidence
Registrational trials decades ago established efficacy in ED; it remains a second-line therapy after PDE5 inhibitors.
Safety and Side Effects
Priapism and penile fibrosis are labeled risks requiring patient training; neonatal use is specialist-only.
Frequently Asked Questions
What is the evidence tier of Alprostadil?
Alprostadil is graded "Approved medicine" on this site. This compound exists as an approved medicine in at least one major jurisdiction. Approval applies to specific, labeled indications and to the regulated product — not to compounded or research-grade copies.
Is Alprostadil an approved medicine?
Alprostadil exists as an approved medicine in at least one major jurisdiction — but approval covers the regulated product and its labeled indications only. Compounded or research-grade versions of the same molecule are not the approved product.
Where can I read the primary studies for Alprostadil?
The references section at the end of this entry links the key primary sources — regulator labels, trial registrations, and peer-reviewed papers. Our "How to Read a Peptide Study" guide explains how to evaluate them.
References
- DailyMed — alprostadil prescribing information. [source]
Evidence tier: Approved medicine · Last reviewed: 2026-09-05 · Sources cited below.